Technology

Our technology depletion zone IsoTachoPhoresis (dzITP) was invented and patented by Prof. THomas Hankemeier at Leiden University. EXIT071 now has an exclusive license for further development and commercialisation of this technology.

Innovation

Our innovative analytical technique – depletion zone isotachophoresis (dzITP) – uses an ion- depleted zone as the basis for enrichment and separation of analytes in a microfluidic chip. The depletion zone acts as an electrical barrier that stops negatively charged analytes of interest passing through, accumulating them into narrow zones at the border of the depletion zone according to their unique electrophoretic mobilities. This feature is responsible for the striking enrichment capabilities of our method. dzITP can also act as a filter – analyte zone that can be selectively released simply by changing the voltage.

Our platform: a convenient, user-friendly format for enrichment, separation, and filtering of analytes.

Exosomes

Exosomes are tiny extracellular vesicles that play a crucial role in intercellular communication. These vesicles are released by various cell types, including both healthy and diseased cells, and can be found in biological fluids such as blood, urine, and saliva. Exosomes are composed of a lipid bilayer membrane encasing a diverse cargo of proteins, lipids, and nucleic acids including microRNAs and messenger RNAs. This cargo reflects the originating cell’s molecular profile, making exosomes valuable biomarkers for diagnostic and therapeutic purposes.

Impact

Exosomes have huge potential for non-invasive diagnostics and novel therapeutics due to their intrinsic properties for regulating intracellular pathways and crossing blood-brain barriers, making them perfect for potential use as drug delivery carriers. Our game-changing technology can offer smooth exosome isolation and biomarker analysis for large amounts of smaples. This will open up novel opportunities to discover and validate exosome biomarkers for disease detection, mechanism of action, companion diagnostics and many other impactful applications!

We are committed to cutting edge science and continuous innovation.

Check out our ongoing projects:

Project: Alive

Interested?

Feel welcome to reach out and we’ll get back to you to answer any questions you may have.

Let’s unlock exosome analysis technology, together.

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